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Computational Assembly of Polymorphic Amyloid Fibrils Reveals Stable Aggregates

Amyloid proteins aggregate into polymorphic fibrils that damage tissues of the brain, nerves, and heart. Experimental and computational studies have examined the structural basis and the nucleation of short fibrils, but the ability to predict and precisely quantify the stability of larger aggregates...

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Detalhes bibliográficos
Main Authors: Smaoui, Mohamed Raef, Poitevin, Frédéric, Delarue, Marc, Koehl, Patrice, Orland, Henri, Waldispühl, Jérôme
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566450/
https://ncbi.nlm.nih.gov/pubmed/23442919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.12.037
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