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Evolutionary conservation of codon optimality reveals hidden signatures of co-translational folding

The choice of codons can influence local translation kinetics during protein synthesis. Whether codon preference is linked to co-translational regulation of polypeptide folding remains unclear. Here, we derive a revised translational efficiency scale that incorporates the competition between tRNA su...

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Detalhes bibliográficos
Main Authors: Pechmann, Sebastian, Frydman, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565066/
https://ncbi.nlm.nih.gov/pubmed/23262490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2466
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