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Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo
The genetic code allows most amino acids a choice of optimal and nonoptimal codons. We report that synonymous codon choice is tuned to promote interaction of nascent polypeptides with the signal recognition particle (SRP), which assists in protein translocation across membranes. Cotranslational reco...
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| Publié dans: | Nat Struct Mol Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4488850/ https://ncbi.nlm.nih.gov/pubmed/25420103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2919 |
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