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Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo
The genetic code allows most amino acids a choice of optimal and nonoptimal codons. We report that synonymous codon choice is tuned to promote interaction of nascent polypeptides with the signal recognition particle (SRP), which assists in protein translocation across membranes. Cotranslational reco...
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| Publicado en: | Nat Struct Mol Biol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4488850/ https://ncbi.nlm.nih.gov/pubmed/25420103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2919 |
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