Aberrant intestinal stem cell lineage dynamics in Peutz–Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt

OBJECTIVE: Genetic predisposition to cancer in Peutz–Jeghers syndrome (PJS) and the role of germline serine–threonine kinase (LKB1) mutations are poorly understood. The authors studied the effect of germline LKB1 mutations on intestinal stem cell dynamics in unaffected flat PJS mucosa. Recent resear...

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Hlavní autoři: Langeveld, Danielle, Jansen, Marnix, de Boer, D V, van Sprundel, Mariska, Brosens, Lodewijk A A, Morsink, Folkert H, Giardiello, Francis M, Offerhaus, G Johan A, de Leng, Wendy W J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564664/
https://ncbi.nlm.nih.gov/pubmed/21940722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300622
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