Aberrant intestinal stem cell lineage dynamics in Peutz–Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt

OBJECTIVE: Genetic predisposition to cancer in Peutz–Jeghers syndrome (PJS) and the role of germline serine–threonine kinase (LKB1) mutations are poorly understood. The authors studied the effect of germline LKB1 mutations on intestinal stem cell dynamics in unaffected flat PJS mucosa. Recent resear...

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Main Authors: Langeveld, Danielle, Jansen, Marnix, de Boer, D V, van Sprundel, Mariska, Brosens, Lodewijk A A, Morsink, Folkert H, Giardiello, Francis M, Offerhaus, G Johan A, de Leng, Wendy W J
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564664/
https://ncbi.nlm.nih.gov/pubmed/21940722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300622
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