Aberrant intestinal stem cell lineage dynamics in Peutz–Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt

OBJECTIVE: Genetic predisposition to cancer in Peutz–Jeghers syndrome (PJS) and the role of germline serine–threonine kinase (LKB1) mutations are poorly understood. The authors studied the effect of germline LKB1 mutations on intestinal stem cell dynamics in unaffected flat PJS mucosa. Recent resear...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Langeveld, Danielle, Jansen, Marnix, de Boer, D V, van Sprundel, Mariska, Brosens, Lodewijk A A, Morsink, Folkert H, Giardiello, Francis M, Offerhaus, G Johan A, de Leng, Wendy W J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564664/
https://ncbi.nlm.nih.gov/pubmed/21940722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300622
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge