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Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building Blocks

The efficient synthesis of an Fmoc-Gly-Ile phosphinic pseudodipeptide was desired as an eventual building block for construction of matrix metalloproteinase inhibitors. A Michael-type addition reaction of bis(tri-methylsilyl) phosphonite with the appropriate acrylate generated the pseudodipeptide bo...

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Bibliografiske detaljer
Main Authors: Bhowmick, Manishabrata, Fields, Gregg B.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564550/
https://ncbi.nlm.nih.gov/pubmed/24496015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10989-012-9307-y
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