PHLPP1 gene deletion protects the brain from ischemic injury

A recently discovered protein phosphatase PHLPP (PH domain Leucine-rich repeat Protein Phosphatase) has been shown to dephosphorylate Akt on its hydrophobic motif (Ser473) thereby decreasing Akt kinase activity. We generated PHLPP1 knockout (KO) mice and used them to explore the ability of enhanced...

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Autors principals: Chen, Bo, Van Winkle, Jessica A, Lyden, Patrick D, Brown, Joan H, Purcell, Nicole H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564187/
https://ncbi.nlm.nih.gov/pubmed/23072745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.150
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