Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy

AIMS: To examine the role of physiological Akt signalling in pathological hypertrophy through analysis of PHLPP1 (PH domain leucine-rich repeat protein phosphatase) knock-out (KO) mice. METHODS AND RESULTS: To investigate the in vivo requirement for ‘physiological’ control of Akt activation in cardi...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Moc, Courtney, Taylor, Amy E., Chesini, Gino P., Zambrano, Cristina M., Barlow, Melissa S., Zhang, Xiaoxue, Gustafsson, Åsa B., Purcell, Nicole H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303795/
https://ncbi.nlm.nih.gov/pubmed/25411382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu243
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