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PHLPP1 gene deletion protects the brain from ischemic injury

A recently discovered protein phosphatase PHLPP (PH domain Leucine-rich repeat Protein Phosphatase) has been shown to dephosphorylate Akt on its hydrophobic motif (Ser473) thereby decreasing Akt kinase activity. We generated PHLPP1 knockout (KO) mice and used them to explore the ability of enhanced...

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Bibliografische gegevens
Hoofdauteurs: Chen, Bo, Van Winkle, Jessica A, Lyden, Patrick D, Brown, Joan H, Purcell, Nicole H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564187/
https://ncbi.nlm.nih.gov/pubmed/23072745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.150
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