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PHLPP1 gene deletion protects the brain from ischemic injury
A recently discovered protein phosphatase PHLPP (PH domain Leucine-rich repeat Protein Phosphatase) has been shown to dephosphorylate Akt on its hydrophobic motif (Ser473) thereby decreasing Akt kinase activity. We generated PHLPP1 knockout (KO) mice and used them to explore the ability of enhanced...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3564187/ https://ncbi.nlm.nih.gov/pubmed/23072745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.150 |
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