Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo

Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids. EETs are formed from arachidonic acid during myocardial ischemia and play a protective role against ischemic cell death. Deletion of sEH has been shown to be protective against myocardial i...

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Autori principali: Motoki, Atsuko, Merkel, Matthias J., Packwood, William H., Cao, Zhiping, Liu, Lijuan, Iliff, Jeffrey, Alkayed, Nabil J., Van Winkle, Donna M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614571/
https://ncbi.nlm.nih.gov/pubmed/18835921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00428.2008
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