Soluble Epoxide Hydrolase Gene Deletion Is Protective Against Experimental Cerebral Ischemia

BACKGROUND AND PURPOSE: Cytochrome P450 epoxygenase metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are produced in the brain and perform important biological functions, including vasodilation and neuroprotection. However, EETs are rapidly metabolized via soluble epoxide hydro...

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Autori principali: Zhang, Wenri, Otsuka, Takashi, Sugo, Nobuo, Ardeshiri, Ardi, Alhadid, Yazan K., Iliff, Jeffrey J., DeBarber, Andrea E., Koop, Dennis R., Alkayed, Nabil J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654189/
https://ncbi.nlm.nih.gov/pubmed/18369166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.107.508325
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