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Soluble epoxide hydrolase gene deletion improves blood flow and reduces infarct size after cerebral ischemia in reproductively senescent female mice

Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilatory epoxyeicosatrienoic acids (EETs), is sexually dimorphic, suppressed by estrogen, and contributes to underlying sex differences in cerebral blood flow and injury after cerebral ischemia. We tested the hypothesis that sEH...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Zuloaga, Kristen L., Zhang, Wenri, Roese, Natalie E., Alkayed, Nabil J.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295540/
https://ncbi.nlm.nih.gov/pubmed/25642188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00290
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