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H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation
Epigenetic silencing in mammals involves DNA methylation and posttranslational modifications of core histones. Here we show that the H1 linker histone plays a key role in regulating both DNA methylation and histone H3 methylation at the H19 and Gtl2 loci in mouse ES cells. Some, but not all, murine...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562819/ https://ncbi.nlm.nih.gov/pubmed/23302691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213266110 |
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