H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

Nearly 50% of mouse and human genomes are composed of repetitive sequences. Transcription of these sequences is tightly controlled during development to prevent genomic instability, inappropriate gene activation and other maladaptive processes. Here, we demonstrate an integral role for H1 linker his...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Healton, Sean E., Pinto, Hugo D., Mishra, Laxmi N., Hamilton, Gregory A., Wheat, Justin C., Swist-Rosowska, Kalina, Shukeir, Nicholas, Dou, Yali, Steidl, Ulrich, Jenuwein, Thomas, Gamble, Matthew J., Skoultchi, Arthur I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322038/
https://ncbi.nlm.nih.gov/pubmed/32513732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920725117
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