H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

Nearly 50% of mouse and human genomes are composed of repetitive sequences. Transcription of these sequences is tightly controlled during development to prevent genomic instability, inappropriate gene activation and other maladaptive processes. Here, we demonstrate an integral role for H1 linker his...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Healton, Sean E., Pinto, Hugo D., Mishra, Laxmi N., Hamilton, Gregory A., Wheat, Justin C., Swist-Rosowska, Kalina, Shukeir, Nicholas, Dou, Yali, Steidl, Ulrich, Jenuwein, Thomas, Gamble, Matthew J., Skoultchi, Arthur I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322038/
https://ncbi.nlm.nih.gov/pubmed/32513732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920725117
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