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Frustration in the energy landscapes of multidomain protein misfolding
Frustration from strong interdomain interactions can make misfolding a more severe problem in multidomain proteins than in single-domain proteins. On the basis of bioinformatic surveys, it has been suggested that lowering the sequence identity between neighboring domains is one of nature’s solutions...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562767/ https://ncbi.nlm.nih.gov/pubmed/23319605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222130110 |
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