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Frustration in the energy landscapes of multidomain protein misfolding

Frustration from strong interdomain interactions can make misfolding a more severe problem in multidomain proteins than in single-domain proteins. On the basis of bioinformatic surveys, it has been suggested that lowering the sequence identity between neighboring domains is one of nature’s solutions...

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Bibliografische gegevens
Hoofdauteurs: Zheng, Weihua, Schafer, Nicholas P., Wolynes, Peter G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562767/
https://ncbi.nlm.nih.gov/pubmed/23319605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222130110
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