An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia

OBJECTIVE: Earlier studies have suggested that a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG). Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic...

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Autori principali: Johansen, Christopher T., Wang, Jian, Lanktree, Matthew B., McIntyre, Adam D., Ban, Matthew R., Martins, Rebecca A., Kennedy, Brooke A., Hassell, Reina G., Visser, Maartje E., Schwartz, Stephen M., Voight, Benjamin F., Elosua, Roberto, Salomaa, Veikko, O’Donnell, Christopher J., Dallinga-Thie, Geesje M., Anand, Sonia S., Yusuf, Salim, Huff, Murray W., Kathiresan, Sekar, Cao, Henian, Hegele, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562702/
https://ncbi.nlm.nih.gov/pubmed/21597005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.226365
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