Excess of Rare Variants in Non-GWAS Candidate Genes in Patients with Hypertriglyceridemia

BACKGROUND: Rare variant accumulation studies can implicate genes in disease susceptibility when a significant burden is observed in patients versus controls. Such analyses might be particularly useful for candidate genes that are selected based on experiments other than genome-wide association stud...

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Huvudupphovsmän: Johansen, Christopher T., Wang, Jian, McIntyre, Adam D., Martins, Rebecca A., Ban, Matthew R., Lanktree, Matthew B., Huff, Murray W., Péterfy, Miklós, Mehrabian, Margarete, Lusis, Aldons J., Kathiresan, Sekar, Anand, Sonia S., Yusuf, Salim, Lee, Ann-Hwee, Glimcher, Laurie H., Cao, Henian, Hegele, Robert A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288444/
https://ncbi.nlm.nih.gov/pubmed/22135386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.111.960864
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