Mutation skew in genes identified by genome-wide association study of hypertriglyceridemia

Genome-wide association studies (GWAS) have replicably identified multiple loci associated with population-based plasma lipid concentrations1-5. Common genetic variants at these loci together explain <10% of the total variation of each lipid trait4,5. Rare variants of individually large effect ma...

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Detalhes bibliográficos
Main Authors: Johansen, Christopher T., Wang, Jian, Lanktree, Matthew B., Cao, Henian, McIntyre, Adam D., Ban, Matthew R., Martins, Rebecca A., Kennedy, Brooke A., Hassell, Reina G., Visser, Maartje E., Schwartz, Stephen M., Voight, Benjamin F., Elosua, Roberto, Salomaa, Veikko, O'Donnell, Christopher J., Dallinga-Thie, Geesje M., Anand, Sonia S., Yusuf, Salim, Huff, Murray W., Kathiresan, Sekar, Hegele, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017369/
https://ncbi.nlm.nih.gov/pubmed/20657596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.628
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