Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Hyperthermia is widely used to treat patients with cancer, especially in combination with other treatments such as radiation therapy. Heat treatment per se activates DNA damage responses mediated by the ATR-Chk1 and ATM-Chk2 pathways but it is not fully understood how these DNA damage responses are...

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Detalhes bibliográficos
Main Authors: Tuul, Munkhbold, Kitao, Hiroyuki, Iimori, Makoto, Matsuoka, Kazuaki, Kiyonari, Shinichi, Saeki, Hiroshi, Oki, Eiji, Morita, Masaru, Maehara, Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562228/
https://ncbi.nlm.nih.gov/pubmed/23383325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055361
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