Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Hyperthermia is widely used to treat patients with cancer, especially in combination with other treatments such as radiation therapy. Heat treatment per se activates DNA damage responses mediated by the ATR-Chk1 and ATM-Chk2 pathways but it is not fully understood how these DNA damage responses are...

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Autori principali: Tuul, Munkhbold, Kitao, Hiroyuki, Iimori, Makoto, Matsuoka, Kazuaki, Kiyonari, Shinichi, Saeki, Hiroshi, Oki, Eiji, Morita, Masaru, Maehara, Yoshihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562228/
https://ncbi.nlm.nih.gov/pubmed/23383325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055361
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