Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Hyperthermia is widely used to treat patients with cancer, especially in combination with other treatments such as radiation therapy. Heat treatment per se activates DNA damage responses mediated by the ATR-Chk1 and ATM-Chk2 pathways but it is not fully understood how these DNA damage responses are...

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Detaylı Bibliyografya
Asıl Yazarlar: Tuul, Munkhbold, Kitao, Hiroyuki, Iimori, Makoto, Matsuoka, Kazuaki, Kiyonari, Shinichi, Saeki, Hiroshi, Oki, Eiji, Morita, Masaru, Maehara, Yoshihiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562228/
https://ncbi.nlm.nih.gov/pubmed/23383325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055361
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