Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP

Motivation: TRAIL has been widely studied for the ability to kill cancer cells selectively, but its clinical usefulness has been hindered by the development of resistance. Multiple compounds have been identified that sensitize cancer cells to TRAIL-induced apoptosis. The drug LY303511 (LY30), combin...

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Bibliografiska uppgifter
Huvudupphovsmän: Shi, Yuan, Mellier, Gregory, Huang, Sinong, White, Jacob, Pervaiz, Shazib, Tucker-Kellogg, Lisa
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Original Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562069/
https://ncbi.nlm.nih.gov/pubmed/23239672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bts702
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