DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

A major base lesion resulting from oxidative stress is 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxoG) that has ambiguous coding potential. Error-free DNA synthesis involves 8-oxoG adopting an anti-conformation to base pair with cytosine whereas mutagenic bypass involves 8-oxoG adopting a syn-conformat...

Full description

Saved in:
Bibliographic Details
Main Authors: Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561998/
https://ncbi.nlm.nih.gov/pubmed/23267011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1276
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items