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DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion
A major base lesion resulting from oxidative stress is 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxoG) that has ambiguous coding potential. Error-free DNA synthesis involves 8-oxoG adopting an anti-conformation to base pair with cytosine whereas mutagenic bypass involves 8-oxoG adopting a syn-conformat...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561998/ https://ncbi.nlm.nih.gov/pubmed/23267011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1276 |
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