Laddar...
DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine
An aerobic environment burdens DNA polymerase substrates with oxidized substrates (DNA and nucleotide pools). A major promutagenic lesion resulting from oxidative stress is 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxoG). Guanine oxidation alters the hydrogen bonding properties of the base and gly...
Sparad:
| Huvudupphovsmän: | , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023916/ https://ncbi.nlm.nih.gov/pubmed/20696268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2010.07.013 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|