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DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine
An aerobic environment burdens DNA polymerase substrates with oxidized substrates (DNA and nucleotide pools). A major promutagenic lesion resulting from oxidative stress is 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxoG). Guanine oxidation alters the hydrogen bonding properties of the base and gly...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023916/ https://ncbi.nlm.nih.gov/pubmed/20696268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2010.07.013 |
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