Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

Whole-genome sequencing using massively parallel sequencing technologies enables accurate detection of somatic rearrangements in cancer. Pinpointing large numbers of rearrangement breakpoints to base-pair resolution allows analysis of rearrangement microhomology and genomic location for every sample...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Drier, Yotam, Lawrence, Michael S., Carter, Scott L., Stewart, Chip, Gabriel, Stacey B., Lander, Eric S., Meyerson, Matthew, Beroukhim, Rameen, Getz, Gad
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561864/
https://ncbi.nlm.nih.gov/pubmed/23124520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.141382.112
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