Absolute quantification of somatic DNA alterations in human cancer

We developed a computational method (ABSOLUTE) that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. ABSOLUTE can detect subclonal heterogeneity, somatic homozygosity, and calculate statistical sensitivity to detect specific aberrations. We used ABSOLU...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Carter, Scott L., Cibulskis, Kristian, Helman, Elena, McKenna, Aaron, Shen, Hui, Zack, Travis, Laird, Peter W., Onofrio, Robert C., Winckler, Wendy, Weir, Barbara A., Beroukhim, Rameen, Pellman, David, Levine, Douglas A., Lander, Eric S., Meyerson, Matthew, Getz, Gad
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383288/
https://ncbi.nlm.nih.gov/pubmed/22544022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2203
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