Engineering Visual Arrestin-1 with Special Functional Characteristics

Arrestin-1 preferentially binds active phosphorylated rhodopsin. Previously, a mutant with enhanced binding to unphosphorylated active rhodopsin (Rh*) was shown to partially compensate for lack of rhodopsin phosphorylation in vivo. Here we showed that reengineering of the receptor binding surface of...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Vishnivetskiy, Sergey A., Chen, Qiuyan, Palazzo, Maria C., Brooks, Evan K., Altenbach, Christian, Iverson, Tina M., Hubbell, Wayne L., Gurevich, Vsevolod V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561558/
https://ncbi.nlm.nih.gov/pubmed/23250748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445437
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