Engineering Visual Arrestin-1 with Special Functional Characteristics

Arrestin-1 preferentially binds active phosphorylated rhodopsin. Previously, a mutant with enhanced binding to unphosphorylated active rhodopsin (Rh*) was shown to partially compensate for lack of rhodopsin phosphorylation in vivo. Here we showed that reengineering of the receptor binding surface of...

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Detalhes bibliográficos
Main Authors: Vishnivetskiy, Sergey A., Chen, Qiuyan, Palazzo, Maria C., Brooks, Evan K., Altenbach, Christian, Iverson, Tina M., Hubbell, Wayne L., Gurevich, Vsevolod V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561558/
https://ncbi.nlm.nih.gov/pubmed/23250748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445437
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