Towards germline gene therapy of inherited mitochondrial diseases

Mutations in mitochondrial DNA (mtDNA) are associated with serious human diseases and inherited from mother's eggs. Here we investigated the feasibility of mtDNA replacement in human oocytes by spindle transfer (ST). Of 106 human oocytes donated for research, 65 were subjected to reciprocal ST...

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Autori principali: Tachibana, Masahito, Amato, Paula, Sparman, Michelle, Woodward, Joy, Sanchis, Dario Melguizo, Ma, Hong, Gutierrez, Nuria Marti, Tippner-Hedges, Rebecca, Kang, Eunju, Lee, Hyo-Sang, Ramsey, Cathy, Masterson, Keith, Battaglia, David, Lee, David, Wu, Diana, Jensen, Jeffrey, Patton, Phillip, Gokhale, Sumita, Stouffer, Richard, Mitalipov, Shoukhrat
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561483/
https://ncbi.nlm.nih.gov/pubmed/23103867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11647
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