Towards germline gene therapy of inherited mitochondrial diseases

Mutations in mitochondrial DNA (mtDNA) are associated with serious human diseases and inherited from mother's eggs. Here we investigated the feasibility of mtDNA replacement in human oocytes by spindle transfer (ST). Of 106 human oocytes donated for research, 65 were subjected to reciprocal ST...

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Detalhes bibliográficos
Main Authors: Tachibana, Masahito, Amato, Paula, Sparman, Michelle, Woodward, Joy, Sanchis, Dario Melguizo, Ma, Hong, Gutierrez, Nuria Marti, Tippner-Hedges, Rebecca, Kang, Eunju, Lee, Hyo-Sang, Ramsey, Cathy, Masterson, Keith, Battaglia, David, Lee, David, Wu, Diana, Jensen, Jeffrey, Patton, Phillip, Gokhale, Sumita, Stouffer, Richard, Mitalipov, Shoukhrat
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561483/
https://ncbi.nlm.nih.gov/pubmed/23103867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11647
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