Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck

The timing and mechanisms of mitochondrial DNA (mtDNA) segregation and transmission in mammals are poorly understood. Genetic bottleneck in female germ cells has been proposed as the main phenomenon responsible for rapid intergenerational segregation of heteroplasmic mtDNA. We demonstrate here that...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lee, Hyo-Sang, Ma, Hong, Juanes, Rita Cervera, Tachibana, Masahito, Sparman, Michelle, Woodward, Joy, Ramsey, Cathy, Xu, Jing, Kang, Eun-Ju, Amato, Paula, Mair, Georg, Steinborn, Ralf, Mitalipov, Shoukhrat
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372871/
https://ncbi.nlm.nih.gov/pubmed/22701816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.011
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