Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck

The timing and mechanisms of mitochondrial DNA (mtDNA) segregation and transmission in mammals are poorly understood. Genetic bottleneck in female germ cells has been proposed as the main phenomenon responsible for rapid intergenerational segregation of heteroplasmic mtDNA. We demonstrate here that...

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Detalhes bibliográficos
Main Authors: Lee, Hyo-Sang, Ma, Hong, Juanes, Rita Cervera, Tachibana, Masahito, Sparman, Michelle, Woodward, Joy, Ramsey, Cathy, Xu, Jing, Kang, Eun-Ju, Amato, Paula, Mair, Georg, Steinborn, Ralf, Mitalipov, Shoukhrat
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372871/
https://ncbi.nlm.nih.gov/pubmed/22701816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.011
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