Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck

The timing and mechanisms of mitochondrial DNA (mtDNA) segregation and transmission in mammals are poorly understood. Genetic bottleneck in female germ cells has been proposed as the main phenomenon responsible for rapid intergenerational segregation of heteroplasmic mtDNA. We demonstrate here that...

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Autori principali: Lee, Hyo-Sang, Ma, Hong, Juanes, Rita Cervera, Tachibana, Masahito, Sparman, Michelle, Woodward, Joy, Ramsey, Cathy, Xu, Jing, Kang, Eun-Ju, Amato, Paula, Mair, Georg, Steinborn, Ralf, Mitalipov, Shoukhrat
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372871/
https://ncbi.nlm.nih.gov/pubmed/22701816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.011
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