Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck

The timing and mechanisms of mitochondrial DNA (mtDNA) segregation and transmission in mammals are poorly understood. Genetic bottleneck in female germ cells has been proposed as the main phenomenon responsible for rapid intergenerational segregation of heteroplasmic mtDNA. We demonstrate here that...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Hyo-Sang, Ma, Hong, Juanes, Rita Cervera, Tachibana, Masahito, Sparman, Michelle, Woodward, Joy, Ramsey, Cathy, Xu, Jing, Kang, Eun-Ju, Amato, Paula, Mair, Georg, Steinborn, Ralf, Mitalipov, Shoukhrat
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372871/
https://ncbi.nlm.nih.gov/pubmed/22701816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.011
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