Belatacept and Sirolimus Prolong Nonhuman Primate Islet Allograft Survival: adverse consequences of concomitant alefacept therapy

Calcineurin inhibitors (CNI) and steroids are known to promote insulin resistance, and their avoidance after islet transplantation is preferred from a metabolic standpoint. Belatacept, a B7-specific mediator of costimulation blockade (CoB), is clinically indicated as a CNI alternative in renal trans...

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Bibliographic Details
Main Authors:	Lowe, MC, Badell, IR, Turner, AP, Thompson, PW, Leopardi, FV, Strobert, EA, Larsen, CP, Kirk, AD
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3558637/ https://ncbi.nlm.nih.gov/pubmed/23279640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2012.04341.x
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Belatacept and Sirolimus Prolong Nonhuman Primate Islet Allograft Survival: adverse consequences of concomitant alefacept therapy

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