Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging.

The deubiquitinating enzyme, USP14, found in association with the proteasome is essential in mediating ubiquitin trimming and in ensuring ubiquitin-homeostasis. As aging is accompanied by a significant decline in proteasomal proteolysis in primary human T lymphocytes, we evaluated the contributory r...

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Hauptverfasser: Ponnappan, Subramaniam, Palmieri, Michela, Sullivan, Dennis H., Ponnappan, Usha
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558606/
https://ncbi.nlm.nih.gov/pubmed/23291607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.12.007
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