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Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus
Cerebral cavernous malformations (CCM) are neurovascular dysplasias affecting up to 0.5% of the population. Mutations in the CCM2 gene are associated with acquisition of CCM. We identify a previously uncharacterized domain at the C-terminus of CCM2 and determine its 1.9 Å resolution crystal structur...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558538/ https://ncbi.nlm.nih.gov/pubmed/23266514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.12.011 |
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