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Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology

Cerebral cavernous malformations (CCM) are neurovascular dysplasias that result in mulberry-shaped lesions predominantly located in brain and spinal tissues. Mutations in three genes are associated with CCM. These genes encode for the proteins KRIT1/CCM1 (krev interaction trapped 1/cerebral cavernou...

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Bibliographic Details
Main Authors: Fisher, Oriana S., Boggon, Titus J.
Format: Artigo
Language:Inglês
Published: Springer Basel 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999170/
https://ncbi.nlm.nih.gov/pubmed/24287896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-013-1532-9
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