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Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity
CCM3 mutations are associated with cerebral cavernous malformation (CCM), a disease affecting 0.1–0.5% of the human population. CCM3 (PDCD10, TFAR15) is thought to form a CCM complex with CCM1 and CCM2; however, the molecular basis for these interactions is not known. We have determined the 2.5 Å cr...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911348/ https://ncbi.nlm.nih.gov/pubmed/20489202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128470 |
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