Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

CCM3 mutations are associated with cerebral cavernous malformation (CCM), a disease affecting 0.1–0.5% of the human population. CCM3 (PDCD10, TFAR15) is thought to form a CCM complex with CCM1 and CCM2; however, the molecular basis for these interactions is not known. We have determined the 2.5 Å cr...

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Bibliographic Details
Main Authors:	Li, Xiaofeng, Zhang, Rong, Zhang, Haifeng, He, Yun, Ji, Weidong, Min, Wang, Boggon, Titus J.
Format:	Artigo
Language:	Inglês
Published:	American Society for Biochemistry and Molecular Biology 2010
Subjects:	Protein Structure and Folding
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2911348/ https://ncbi.nlm.nih.gov/pubmed/20489202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128470
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Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

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