Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations

Familial cerebral cavernous malformations (CCMs) are predominantly neurovascular lesions and are associated with mutations within the KRIT1, CCM2, and PDCD10 genes. The protein products of KRIT1 and CCM2 (Krev interaction trapped 1 (KRIT1) and cerebral cavernous malformations 2 (CCM2), respectively)...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Fisher, Oriana S., Liu, Weizhi, Zhang, Rong, Stiegler, Amy L., Ghedia, Sondhya, Weber, James L., Boggon, Titus J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317034/
https://ncbi.nlm.nih.gov/pubmed/25525273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616433
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