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Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations

Familial cerebral cavernous malformations (CCMs) are predominantly neurovascular lesions and are associated with mutations within the KRIT1, CCM2, and PDCD10 genes. The protein products of KRIT1 and CCM2 (Krev interaction trapped 1 (KRIT1) and cerebral cavernous malformations 2 (CCM2), respectively)...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Fisher, Oriana S., Liu, Weizhi, Zhang, Rong, Stiegler, Amy L., Ghedia, Sondhya, Weber, James L., Boggon, Titus J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317034/
https://ncbi.nlm.nih.gov/pubmed/25525273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616433
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