Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations

Familial cerebral cavernous malformations (CCMs) are predominantly neurovascular lesions and are associated with mutations within the KRIT1, CCM2, and PDCD10 genes. The protein products of KRIT1 and CCM2 (Krev interaction trapped 1 (KRIT1) and cerebral cavernous malformations 2 (CCM2), respectively)...

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Pubblicato in:J Biol Chem
Autori principali: Fisher, Oriana S., Liu, Weizhi, Zhang, Rong, Stiegler, Amy L., Ghedia, Sondhya, Weber, James L., Boggon, Titus J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317034/
https://ncbi.nlm.nih.gov/pubmed/25525273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616433
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