MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systemati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lin, Shibo, Hoffmann, Katrin, Xiao, Zhi, Jin, Nan, Galli, Uwe, Mohr, Elvira, Büchler, Markus W, Schemmer, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2013
Pynciau:
Primary Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558388/
https://ncbi.nlm.nih.gov/pubmed/23320839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-13-3
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