MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systemati...

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Библиографические подробности
Главные авторы: Lin, Shibo, Hoffmann, Katrin, Xiao, Zhi, Jin, Nan, Galli, Uwe, Mohr, Elvira, Büchler, Markus W, Schemmer, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
Предметы:
Primary Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558388/
https://ncbi.nlm.nih.gov/pubmed/23320839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-13-3
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