MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systemati...

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Detalhes bibliográficos
Main Authors: Lin, Shibo, Hoffmann, Katrin, Xiao, Zhi, Jin, Nan, Galli, Uwe, Mohr, Elvira, Büchler, Markus W, Schemmer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558388/
https://ncbi.nlm.nih.gov/pubmed/23320839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-13-3
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