Theoretical Investigations and Density Functional Theory Based Quantitative Structure–Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes

[Image: see text] Octahedral platinum(IV) complexes are promising candidates in the fight against cancer. In order to rationalize the further development of this class of compounds, detailed studies on their mechanisms of action, toxicity, and resistance must be provided and structure–activity relat...

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Κύριοι συγγραφείς: Varbanov, Hristo P., Jakupec, Michael A., Roller, Alexander, Jensen, Frank, Galanski, Markus, Keppler, Bernhard K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2012
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557934/
https://ncbi.nlm.nih.gov/pubmed/23214999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3016427
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