Allostery Mediates Ligand Binding to Grb2 Adaptor in a Mutually Exclusive Manner

Allostery plays a key role in dictating the stoichiometry and thermodynamics of multi-protein complexes driving a plethora of cellular processes central to health and disease. Herein, using various biophysical tools, we demonstrate that although Sos1 nucleotide exchange factor and Gab1 docking prote...

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Main Authors: McDonald, Caleb B., El Hokayem, Jimmy, Zafar, Nawal, Balke, Jordan E., Bhat, Vikas, Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Farooq, Amjad
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557811/
https://ncbi.nlm.nih.gov/pubmed/23334917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2256
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