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Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes
A monoclonal antibody against the C-type lectin DEC205 (αDEC205) is an effective vehicle for delivery of antigens to dendritic cells through creation of covalent αDEC205–antigen adducts. These adducts can induce antigen-specific T-cell immune responses or tolerance. We exploit the transpeptidase act...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557095/ https://ncbi.nlm.nih.gov/pubmed/23297227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214994110 |
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