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Lipid Modification of Proteins through Sortase-Catalyzed Transpeptidation
A general chemoenzymatic method for the site-specific attachment of lipids to protein substrates is described. Sortase A is used to append short lipid-modified oligoglycine peptides to the C terminus of protein substrates bearing a five amino acid sortase A recognition sequence (LPETG). We demonstra...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2647021/ https://ncbi.nlm.nih.gov/pubmed/18989959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja806779e |
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